LUCARD (Lung Cancer Residual Disease Study)
LUCARD (Lung Cancer Residual Disease Study) is the study of minimal residual disease (MRD) in non-small cell lung cancer (NSCLC).
The main objectives are:
- to evaluate and demonstrate the utility of identifying MRD as prognostic biomarker for patients with operable NSCLC (Stage II-IIIa). (MRD is defined as presence of ctDNA in plasma 5-8 days after surgery and at later timepoint),
- to assess the frequency of detection of variants in plasma at distal timepoints in patients initially classed as MRD-negative, and association between these findings and clinically/radiologically detected recurrence and progression,
- to evaluate the qualitative and quantitative correlation between variants detected across the continuum of pre-surgery plasma -> tumor tissue -> post-surgery plasma (all timepoints), for genes associated with targeted therapy,
- to assess the relationship between MRD+ and MRD- status and clinical factors:
- TNM, type of surgery, histological type of tumor, size of tumor, localization of affected lymph nodes, smoking status,
- to analyze the correlation between MRD-, MRD+ status and tTMB.
The expected result of the study:
- increased accuracy of prognosis and prediction of cancer recurrence.
- improved understanding and effectiveness of neoadjuvant and adjuvant targeted- and immuno-therapy.
Four leading medical centers in Russia and more than 200 patients are currently involved in the study.
The ultimate ambition of LUCARD is to implement practical and cost-effective methodology for predicting and detecting cancer recurrence.